The Fox Lab at Duke University

Broken chromosomes heading into mitosis: more than one way to patch a flat tire.

Conserved chamber-specific polyploidy maintains heart function in Drosophila.

​

​

Profile of this paper

Measuring Cellular Ploidy In Situ by Light Microscopy.

Conserved Function of Drosophila Fancd2 Monoubiquitination In Response to Double-Strand DNA Breaks.

Distinct responses to rare codons in select Drosophila tissues.

​

​

Profile of this paper

Regeneration. 

​

​

​

​

Persistent DNA Damage Signaling and DNA Polymerase Theta Promote Broken Chromosome Segregation.

DNA Damage Responses during the Cell Cycle: Insights from Model Organisms and Beyond.

Communal living: the role of polyploidy and syncytia in tissue biology.

​

Accelerated cell cycles enable organ regeneration under developmental time constraints in the Drosophila hindgut.

​

Profile of this paper

Exploiting codon usage identifies intensity-specific modifiers of Ras/MAPK signaling in vivo.

Cytoplasmic sharing through apical junction remodeling.

​

Profile of this paper

Toxicological study and genetic basis of BTEX susceptibility in Drosophila melanogaster. 

Polyploidy: a biological force from cells to ecosystems. 

Model systems for regeneration: Drosophila.

Physiology, development, and disease modeling in the Drosophila excretory system.

Interphase cohesin regulation ensures mitotic fidelity after genome reduplication.

​

Cover Image

Fizzy-related dictates a cell cycle switch during organ repair and tissue growth responses in the Drosophila hindgut.

​

Profile of this paper

Polyploidy and mitotic cell death are two distinct HIV-1 VPR-driven outcomes in renal tubule epithelial cells. 

Polyteny: still a giant player in chromosome research.

Interorgan regulation of Drosophila intestinal stem cell proliferation by a hybrid organ boundary zone.

​

Profile of this paper

Distinct responses to reduplicated chromosomes require distinct Mad2 responses.

​

Profile of this paper

Proliferation of double-strand break-resistant polyploid cells requires Drosophila Fancd2.

​

​

Profile of this paper

The expanding implications of polyploidy.

​

Profile of this paper

Indispensable pre-mitotic endocycles promote aneuploidy in the Drosophila rectum.

​

​

​

Polyploidization and cell fusion contribute to wound healing in the adult Drosophila epithelium.  

​

Profile of this paper

Endoreplication and polyploidy: insights into development and disease.

Error-prone polyploid mitosis during normal Drosophila development.

​

Profile of this paper

The Drosophila hindgut lacks constitutively active adult stem cells but proliferates in response to tissue damage.

​

Profile of this paper