The Fox Lab at Duke University

Integrating the Study of Polyploidy Across Organisms, Tissues, and Disease.

Orb2 enables rare-codon-enriched mRNA expression during Drosophila neuron differentiation.

Broken chromosomes heading into mitosis: more than one way to patch a flat tire.

Conserved chamber-specific polyploidy maintains heart function in Drosophila.

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Measuring Cellular Ploidy In Situ by Light Microscopy.

Conserved Function of Drosophila Fancd2 Monoubiquitination In Response to Double-Strand DNA Breaks.

Distinct responses to rare codons in select Drosophila tissues.

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Regeneration. 

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Persistent DNA Damage Signaling and DNA Polymerase Theta Promote Broken Chromosome Segregation.

DNA Damage Responses during the Cell Cycle: Insights from Model Organisms and Beyond.

Communal living: the role of polyploidy and syncytia in tissue biology.

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Accelerated cell cycles enable organ regeneration under developmental time constraints in the Drosophila hindgut.

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Exploiting codon usage identifies intensity-specific modifiers of Ras/MAPK signaling in vivo.

Cytoplasmic sharing through apical junction remodeling.

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Toxicological study and genetic basis of BTEX susceptibility in Drosophila melanogaster. 

Polyploidy: a biological force from cells to ecosystems. 

Model systems for regeneration: Drosophila.

Physiology, development, and disease modeling in the Drosophila excretory system.

Interphase cohesin regulation ensures mitotic fidelity after genome reduplication.

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Fizzy-related dictates a cell cycle switch during organ repair and tissue growth responses in the Drosophila hindgut.

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Polyploidy and mitotic cell death are two distinct HIV-1 VPR-driven outcomes in renal tubule epithelial cells. 

Polyteny: still a giant player in chromosome research.

Interorgan regulation of Drosophila intestinal stem cell proliferation by a hybrid organ boundary zone.

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Distinct responses to reduplicated chromosomes require distinct Mad2 responses.

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Proliferation of double-strand break-resistant polyploid cells requires Drosophila Fancd2.

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The expanding implications of polyploidy.

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Indispensable pre-mitotic endocycles promote aneuploidy in the Drosophila rectum.

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Polyploidization and cell fusion contribute to wound healing in the adult Drosophila epithelium.  

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Endoreplication and polyploidy: insights into development and disease.

Error-prone polyploid mitosis during normal Drosophila development.

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The Drosophila hindgut lacks constitutively active adult stem cells but proliferates in response to tissue damage.

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